Proto-Oncogene Proteins c-kit

A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.

Also Known As:

Proto-Oncogene Protein c-kit; CD117 Antigen; Proto-Oncogene Protein kit; SCF Receptor; p145 c-kit; p145c-kit; Proto Oncogene Protein c kit; Proto Oncogene Protein kit; Proto Oncogene Proteins c kit; Proto-Oncogene Protein, kit; c kit Protein; c kit Receptor; c-kit, Proto-Oncogene Protein; c-kit, Proto-Oncogene Proteins; c-kit, p145; kit Proto Oncogene Protein; p145 c kit; p145c kit; Antigens, CD117; CD117 Antigens; Receptor, Stem Cell Factor; Stem Cell Factor Receptor; c-kit Protein; c-kit Receptor; kit Proto-Oncogene Protein; p145(c-kit)

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein-Tyrosine Kinases: 7697
        Receptor Protein-Tyrosine Kinases: 5999
        Proto-Oncogene Proteins c-kit: 471
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Receptor Protein-Tyrosine Kinases: 5999
        Proto-Oncogene Proteins c-kit: 471
      - Peptide Receptors: 1159
        Growth Factor Receptors: 2663
        Colony-Stimulating Factor Receptors: 28
        Proto-Oncogene Proteins c-kit: 471
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Colony-Stimulating Factor Receptors: 28
        Proto-Oncogene Proteins c-kit: 471
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7697
      - Receptor Protein-Tyrosine Kinases: 5999
        Proto-Oncogene Proteins c-kit: 471
  - Neoplasm Proteins: 2
    - Oncogene Proteins: 7793
      - Proto-Oncogene Proteins: 7
        Proto-Oncogene Proteins c-kit: 471

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Disease

Drug/Important Bio-Agent (IBA)